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OuterHairCell

sc_neurocore_engine::neurons::sensory

Struct OuterHairCell 

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pub struct OuterHairCell {
Show 14 fields
    pub v: f64,
    pub v_rest: f64,
    pub tau: f64,
    pub g_met: f64,
    pub x_half: f64,
    pub s_met: f64,
    pub motility: f64,
    pub l_max: f64,
    pub v_pk: f64,
    pub z_e: f64,
    pub v_t: f64,
    pub q_max: f64,
    pub asym_factor: f64,
    pub dt: f64,

}
Expand description

Outer hair cell — cochlear amplifier via prestin electromotility.

Prestin (SLC26A5) is a voltage-dependent motor protein that contracts the OHC soma upon depolarisation and elongates upon hyperpolarisation. This bidirectional response is asymmetric: maximum contraction exceeds maximum elongation (~2:1 ratio).

The model implements:

  1. MET transduction (stereocilia → receptor potential)
  2. Prestin electromotility with two-state Boltzmann charge movement and asymmetric length change
  3. Nonlinear capacitance (NLC) that peaks near V_pk

Prestin motility (Santos-Sacchi 2006): charge = Q_max / (1 + exp(z_e*(V-V_pk)/(kT))) ΔL = L_max * (charge/Q_max - 0.5) * asym(V)

where asym(V) = 1 + a_factor*(V-V_pk)/|V-V_pk+eps| gives asymmetric contraction (depolarised) vs elongation (hyperpolarised).

Dallos et al., Neuron 58:333, 2008. Santos-Sacchi et al., J Neurosci 26:3992, 2006.

Fields§

§v: f64§v_rest: f64§tau: f64§g_met: f64§x_half: f64§s_met: f64§motility: f64§l_max: f64§v_pk: f64§z_e: f64§v_t: f64§q_max: f64§asym_factor: f64§dt: f64

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impl OuterHairCell

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pub fn new() -> Self

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fn prestin_compact(&self) -> f64

Two-state Boltzmann charge transfer. Returns fraction of prestin in compact state [0, 1].

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pub fn step(&mut self, displacement: f64) -> f64

Step with displacement (nm). Returns receptor potential (mV).

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pub fn reset(&mut self)

Trait Implementations§

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impl Clone for OuterHairCell

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fn clone(&self) -> OuterHairCell

Returns a duplicate of the value. Read more
1.0.0 (const: unstable) · Source§

fn clone_from(&mut self, source: &Self)

Performs copy-assignment from source. Read more
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impl Debug for OuterHairCell

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fn fmt(&self, f: &mut Formatter<'_>) -> Result

Formats the value using the given formatter. Read more
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impl Default for OuterHairCell

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fn default() -> Self

Returns the “default value” for a type. Read more

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fn borrow_mut(&mut self) -> &mut T

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impl<T> CloneToUninit for T
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unsafe fn clone_to_uninit(&self, dest: *mut u8)

🔬This is a nightly-only experimental API. (clone_to_uninit)
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